Model Systems in Aging

Model Systems in Aging

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Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the development of testable hypothesis concerning aging in an evolutionary context, a unifying theory of the molecular/physiological mechanistic causes of aging has not been reached. In fact, is it not clear to what extent aging is a programmed or stochastic process. This book takes the reader from unicellular bacterial deterioration via senescence in fungi and worms to aging in rodents and humans, allowing a comparative view on similarities and differences in different genetic model systems. The different model systems are scrutinized in the light of contemporary aging hypothesis, such as the free radical and genomic instability theories.Another interaction between these genes was found at the level of oxidative stress resistance (Honda and Honda 1999). Adults of the single mutant clk-1 do not show any sod-3 expression at all while in the long-lived daf-2 the expression ofanbsp;...

Title:Model Systems in Aging
Author: Heinz D. Osiewacz
Publisher:Springer Science & Business Media - 2004

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